Studies
Colorectal Cancer Risk After Age 75 Dwarfed by Other Mortality Causes
For millions of older adults who dutifully undergo repeat colonoscopies after a prior polyp finding, a growing body of evidence is challenging whether…
Search Results: "longevity"
Found 1260 results for "longevity"
⚕️ Synthesized briefings — original sources linked for full context.
Studies
Human Mini-Organs Reshape Drug Testing Beyond Animal Model Limitations
The reliability gap between animal studies and human clinical outcomes has long been one of biomedical research's most stubborn problems — and a quiet…
Studies
Gestational Hypertension Surged 73% in Eight Years, CDC Data Show
A quiet epidemic in maternal health has accelerated sharply over the past decade, with implications that extend well beyond the delivery room…
Longevity
Newly Identified PTCHD4 Protein Drives Cellular Senescence Via AKT Signaling
Understanding which molecular switches accelerate biological aging has become one of the most consequential questions in longevity medicine. A previously…
Longevity
Self-Efficacy Outweighs Physical Function in Predicting Successful Aging at 85+
What separates those who thrive in their late eighties from those who merely survive may have less to do with physical capacity than previously assumed. For…
Nutrition
GLP-1 Drugs Shrink Fat and Muscle: What the Lean Mass Loss Actually Means
As semaglutide and tirzepatide reshape obesity medicine, a critical question has emerged that the weight-loss headlines routinely bury: what happens to the…
Longevity
Hepatokine HPS Activates AMPK to Reverse Age-Related Liver Senescence
Circulating and intrahepatic Hepassocin (HPS) levels decline with age in both mice and elderly humans, and this drop directly impairs hepatic regeneration. In…
Longevity
IGFBP5 Reverses Stem Cell Senescence via WNT5B, Restoring Bone Regeneration
IGFBP5 expression drops significantly in dental follicle stem cells (DFSCs) undergoing both replicative and oxidative (H₂O₂-induced) senescence. Restoring…
Longevity
Semaglutide Slows 3 Epigenetic Aging Clocks in 32-Week RCT
Semaglutide and related GLP-1 receptor agonists are producing mortality and organ-protection effect sizes that outpace what glycemic control or weight loss…
Longevity
U.S. Stroke-Dementia Deaths Rose 43% Among Elderly Over 25 Years
When nearly one million deaths cluster around two of the most feared conditions in aging — stroke and dementia — the trajectory of those deaths matters…
Studies
Bone Marrow Chip Reveals How Plasma Cells Navigate Immune Memory Niches
Vaccine durability and long-term protection from infection depend not just on whether antibodies are made, but on how long plasma cells survive in the bone…
Longevity
GH Receptor Blockade Extends Mouse Lifespan Up to 265 Days
The relationship between growth hormone signaling and aging has long intrigued longevity researchers, but translatable pharmacological tools have remained…
Longevity
Stopping Statins After 75 Shows No Mortality Increase in Phase 3 Trial
For the millions of older adults who take statins not because they've had a heart attack but simply as a preventive measure, a foundational question has gone…
Studies
Global TB Burden Mapped Across 204 Countries: MDR-TB Progress Assessed
Tuberculosis remains one of the most consequential infectious disease challenges of our era — and a major new systematic analysis now provides the most…
PREPRINTNutrition
Daily Walnuts Cut Gut Dysbiosis Markers 17.6% in Clinical Trial
A clinical trial measuring 11 fecal metabolites found that regulated walnut intake was associated with a 2.8% increase in gut microbial alpha diversity, a…
Longevity
Semaglutide Extends Female Mouse Lifespan Via Calorie-Restriction Pathways
Most GLP-1 drugs are prescribed for blood sugar and weight — but if their longevity effects in mammals generalize beyond metabolic disease, the implications…
Longevity
Semaglutide Extends Lifespan in Aging Mice, Mimicking Calorie Restriction Mechanisms
The GLP-1 drug class has rapidly transformed metabolic medicine, but a fundamental question has lingered: are its benefits simply downstream of weight loss…
Studies
2.7 Billion Still Breathe Second-Hand Smoke Despite Three-Decade Decline
Population growth is quietly erasing decades of public health victories against tobacco exposure. Even as age-standardised rates of second-hand smoke (SHS)…
Longevity
Six Proteomic Clocks Detect Anti-Aging Signals Inside a Phase 2a Drug Trial
Most drugs tested against age-related diseases are never evaluated for whether they also slow biological aging itself — a missed opportunity that could…
Longevity
Rapamycin Boosts Cerebral Blood Flow 15%+ in APOE4 Carriers at Low Dose
A pilot single-arm trial administered 1 mg/day rapamycin for 4 weeks to 23 cognitively normal adults aged 45–65, stratified by APOE4 genotype. Among the nine…