Found 1102 results for "longevity"
The capacity to rebuild damaged muscle tissue erodes with age and disease, making the molecular switches governing muscle stem cell behavior among the most…
Accelerometry data from 2,809 adults in the Northern Finland Birth Cohort 1966 (46-year follow-up) reveals stark occupational divides in how physical…
In 20 pluriparous Alpine dairy goats monitored across three 15-day intervals, acute environmental stress produced measurable, reversible telomere shortening…
How far an older adult ventures from home on a typical week turns out to be one of the most information-dense signals available about their overall health…
In a cross-sectional analysis of 936 U.S. adults paired with single-cell RNA sequencing in exercised mice, higher physical activity levels associated with…
For decades, amyloid plaques have dominated the narrative of Alzheimer's disease pathology — but mounting evidence suggests the full picture is far more…
A single molecular target that, when silenced, simultaneously prevents cognitive decline, muscle wasting, heart dysfunction, and systemic inflammation—that is…
Understanding how neurons maintain mitochondrial health across decades of high metabolic demand may be one of the most consequential questions in longevity…
The idea that your morning coffee might do more than sharpen focus has gained a molecular foothold. Understanding precisely how caffeine interacts with aging…
Bioinformatics analysis of GEO datasets identified 808 differentially expressed genes in osteoarthritis (OA), with neutrophil extracellular trap (NET)…
Food-derived bioactive peptides from plant, animal, and marine sources can extend healthspan and lifespan in model systems by modulating three conserved…
Eating window duration follows a U-shaped mortality curve — a counterintuitive finding that challenges the blanket enthusiasm for aggressive time-restricted…
When artificial intelligence fails in clinical medicine, the culprit is often a mismatch between the curated datasets used for training and the messy…
A Mayo Clinic team proposes a formal classification system called 'senotypes' to organize the profound heterogeneity of senescent cells across five…
Intracellular complement proteins C3 (intC3) and C5 (intC5) — components of what is now termed the 'complosome' — engage in extensive crosstalk with mTOR…
The global shortfall of dementia specialists represents one of the most urgent bottlenecks in neurodegenerative care — millions of patients wait months or…
For decades, chronic low-grade inflammation in older adults was treated as a background condition — an inevitable consequence of aging with modest clinical…
Liver disease rarely announces itself early — by the time metabolic dysfunction-associated steatotic liver disease (MASLD) is clinically apparent, significant…
Precise control over how cells destroy their own proteins sits at the heart of aging, neurodegeneration, and cancer biology. When the proteasome — the cell's…
For decades, the textbook model of G-protein-coupled receptor (GPCR) signaling placed all meaningful activity at the plasma membrane — a tidy picture that…