Found 1260 results for "longevity"
Terbinafine, a widely-used antifungal medication, and miglustat, a rare disease treatment, both extended lifespan in C. elegans by activating mitochondrial…
Popular anti-aging supplements could be inadvertently helping one of medicine's most aggressive cancers resist treatment. This discovery challenges the…
A systematic analysis of 113 studies reveals that while NAD⁺ precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) consistently…
Evolutionary biologist Michael Ringel argues that aging isn't a biological accident but an optimized process shaped by natural selection under resource…
Two previously unknown iridoid glycosides from Verbascum nigrum subspecies abietinum activated multiple stress-resistance pathways in C. elegans worms…
Analysis of 25 rodent longevity models reveals that enhanced blood flow and angiogenesis drive healthful aging in only seven cases, with brown adipose tissue…
Homoharringtonine (HHT), currently FDA-approved for leukemia treatment, selectively eliminates senescent cells in white adipose tissue by binding to heat…
Researchers using 5×FAD Alzheimer's mice discovered that dying brain cells release spermidine, a metabolite that triggers autophagy—the cellular cleanup…
Age-related deterioration in sepsis outcomes may stem from fundamental changes in how our gut bacteria interact with intestinal defenses. This mechanistic…
The discovery that specific long non-coding RNAs orchestrate cellular aging could fundamentally alter how we approach age-related disease prevention. These…
Regular nut consumption emerges as one of the most consistently validated dietary interventions for extending healthy lifespan, with mounting evidence showing…
The vast majority of human genetic variants linked to disease risk lie outside protein-coding regions, creating a massive blind spot in precision medicine…
N-acetylneuraminic acid (Neu5Ac), a sialic acid found in bird's nest and human milk, demonstrated remarkable gut-protective effects in both aging and…
The quest to measure how fast we truly age has moved far beyond counting birthdays. While chronological age ticks uniformly forward, biological age varies…
The cardiovascular field may be witnessing a paradigm shift in how we approach the body's most critical blood pressure pathway. Rather than continuing to…
AI analysis of handheld ultrasound measurements successfully estimated cardiovascular biological age in 243 adults, correlating strongly with chronological…
The ability to reach 100 years while maintaining relatively good health represents one of biology's most intriguing phenomena, yet the metabolic signatures…
The golden hours following a heart attack may determine not just immediate survival, but life expectancy years into the future. This reality takes on new…
The central mystery of human vision—why our sharpest sight depends on a tiny retinal region packed exclusively with red and green light sensors—has been…
IGF-1 signaling operates through a previously unrecognized temporal switch that determines whether cells repair or senesce. Acute IGF-1 exposure promotes…