Found 1102 results for "longevity"
Aspartame at 100 μM concentrations activated autophagy genes (bec-1, unc-51, lgg-1, lgg-2, atg-5) in C. elegans worms, extending lifespan while enhancing…
Lin's research reveals a sophisticated glucose-sensing mechanism where the AXIN:LKB1 complex translocates to lysosomal surfaces when aldolase detects low…
The explosive rise in ultra-processed food consumption across Europe represents a fundamental shift in cancer risk that most adults underestimate. These…
The mystery of why kidney disease accelerates heart failure may finally have a molecular explanation. While cardiovascular complications kill more than half…
Pathogenic gut bacteria and their metabolites accelerate telomere shortening through oxidative stress pathways, while shortened telomeres compromise gut…
Reduced forms of NAD+ precursors—NMNH and NRH—triggered dramatically broader metabolic and transcriptional changes in mouse liver cells compared to their…
One month of rapamycin treatment in reproductively aged 10-month-old female mice suppressed mTOR signaling and reduced cellular senescence, inflammation…
The pursuit of longevity through dietary intervention may have found a previously overlooked molecular pathway that operates independently of the well-studied…
The world's most vulnerable populations remain trapped in cycles of malnutrition despite nearly a decade of coordinated global health initiatives. This…
Just 14 days of head-down tilt bedrest in adults aged 55-65 significantly decreased beneficial gut bacteria including Akkermansia and Lactobacillus while…
Scientists at A*STAR have developed a light-controlled hydrogel system that can adjust tissue stiffness in real-time, revealing how mechanical changes in…
Scientists identified ribonuclease κ (RNASEK) as a critical enzyme that degrades circular RNAs (circRNAs), which accumulate toxically in aging cells. RNASEK…
Researchers identified MPOL_B_1, a novel geroprotector compound that extends C. elegans lifespan by up to 30% through virtual screening targeting the…
Advanced mapping techniques reveal that sympathetic nerve density increases in aging ovaries across both human and mouse models, with nerve ablation…
Bioengineers have created artificial liver environments using decellularized extracellular matrix scaffolds that successfully induce dormancy in colorectal…
Clinical evidence reveals semaglutide's therapeutic effects extend far beyond its original diabetes indication, with documented benefits across cardiovascular…
CRISPR-edited human cord blood stem cells carrying the GATA2-R398W mutation display severe mitotic dysfunction and accelerated aging signatures that…
The nonoxidative pentose phosphate pathway, orchestrated by enzymes transketolase and transaldolase, emerges as a critical regulator of CD8+ T cell function…
HDAC3, a histone deacetylase enzyme, directly regulates the Hippo signaling pathway through acetylation modifications of the Hpo protein, revealing a novel…
Moss species in thawing Arctic permafrost regions are emerging as unexpected nitrogen suppliers, compensating for nutrient limitations that typically…