Found 1102 results for "longevity"
Virtual screening reveals 4,4'-diapophytofluene (4,4'-DPE), extracted from coconut leaves, demonstrates stronger binding affinity to five critical…
ABT-263, a drug that eliminates senescent cells by blocking anti-apoptotic proteins Bcl-xL and activating Bax, showed dramatically different effects in two…
Scientists at PNAS have developed a novel bioconjugation technique using activated allylic bromides to selectively modify methionine amino acid residues in…
Researchers developed an artificial intelligence system that predicts where lysine residues undergo post-translational modifications by combining protein…
A comprehensive analysis tracking pain patterns across 22 countries reveals a concerning upward trajectory in chronic pain prevalence among adults aged 50 and…
Research demonstrates that menopausal estrogen withdrawal triggers accelerated accumulation of amyloid-beta plaques and tau tangles in female brains, while…
Despite Thailand's international reputation for transgender acceptance and medical expertise, transgender adults face systematic exclusion from the country's…
C. elegans research reveals a crucial distinction between living longer and aging well. While seven tested compounds universally extended male worm lifespan…
GLOD4 protein actively directs peroxynitrite-mediated nitration to specific cellular targets, contradicting decades of assumptions that this oxidative damage…
Analysis of Indian demographic data reveals that years of schooling demonstrate a stronger inverse relationship with premature adult mortality than household…
French researchers have mapped the mechanisms by which mitochondria migrate between adjacent cells, particularly within tumor environments. This intercellular…
Nondaily and low-intensity smokers in Latin America present distinct cessation challenges that differ markedly from heavy daily users. These lighter smoking…
A consortium of aging researchers has advanced a unified theoretical framework positioning cellular and molecular replacement as the primary mechanism for…
Researchers analyzing aging data found that pain intensity systematically degrades intrinsic capacity—the combination of physical and mental abilities that…
Mendelian randomization analysis reveals that while interleukin-6 (IL-6) increases mortality risk, its soluble receptor (sIL-6R) demonstrates the opposite…
Analysis of 12,906 Chinese adults revealed that accumulating multiple age-related functional impairments creates a more powerful mortality predictor than any…
France has implemented the WHO's Integrated Care for Older People (ICOPE) framework as a nationwide program, representing the first large-scale deployment of…
Mammary gland involution following weaning triggers widespread cellular senescence that orchestrates tissue remodeling but simultaneously creates…
White adipose tissue accumulation around abdominal organs during midlife follows predictable patterns, but its metabolic consequences depend heavily on…
NIA researchers created a novel mouse model that captures the cascade of inflammatory processes underlying simultaneous deterioration across multiple organ…