Exercise Modulates Brain p21 Senescence Signals Via Dose-Dependent Three-State Model
The cyclin-dependent kinase inhibitor p21 (CDKN1A) behaves in fundamentally opposing ways across exercise contexts in the aging brain. Sustained physiological…
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The cyclin-dependent kinase inhibitor p21 (CDKN1A) behaves in fundamentally opposing ways across exercise contexts in the aging brain. Sustained physiological…
Sarcopenia silently erodes independence long before most people recognize it as a threat — and the timing of meals, not just their content, may be a…
The promise of epigenetic clocks has always been tantalizing: a molecular readout of how fast you're actually aging, responsive enough to detect whether an…
Analyzing weekly all-cause mortality data from 31 European countries (2015 onward, COVID-19 period excluded from baseline), NeMMo — an evolution of the…
When public health surveillance operates at the wrong geographic scale, it can miss a crisis building in plain sight. That appears to be precisely what…
When two serious vascular conditions overlap, outcomes worsen dramatically — yet the therapeutic toolkit remains surprisingly thin. For the millions of adults…
With dementia cases projected to surge most dramatically in lower-income regions, the uncomfortable reality is that nearly all prevention research has been…
In a triple-blinded RCT, 51 men aged ≥65 with type 2 diabetes were randomized to resistance training plus either a control, protein supplementation (P), or…
For decades, metformin has attracted intense interest as a potential longevity-extending compound beyond its glucose-lowering role — a hypothesis now being…
The intense scientific interest in repurposing a decades-old diabetes drug as a broad anti-aging intervention has reached a critical inflection point. A…
For the millions of adults who spend eight or more hours seated daily, the cognitive cost of uninterrupted sitting has long been a concern. This meta-analysis…
Personalized medicine is reaching geroscience in a meaningful way, and PROMETHEUS represents one of the more structured attempts to operationalize that idea…
Among 311 postpartum women in the PETALS-2 prospective cohort, each one-unit increase in intrinsic motivation (IM) score was associated with 42% greater…
For decades, coronary heart disease has been framed almost entirely as a consequence of individual choices — diet, exercise, smoking. A growing body of…
The explosive adoption of GLP-1 receptor agonists has outpaced understanding of what happens when patients stop taking them — a gap that matters enormously…
A massive multi-ancestry genome-wide association study spanning 345,687 heart failure cases across 4.47 million individuals uncovered 383 genomic loci — 166…
For the roughly 40% of adults with obesity who face elevated lung cancer risk, a growing body of evidence suggests the immune system — not just metabolism…
For the millions of adults living with psychosis-spectrum conditions, negative symptoms — the flattening of motivation, pleasure, and goal-directed behavior…
When a young athlete collapses and dies on a field, the tragedy extends far beyond one individual — because the genetic variant responsible may be silently…
For the millions of adults who struggle to meet formal exercise guidelines, the staircase may represent one of the most accessible cardiovascular…