Found 1260 results for "longevity"
Pathogenic gut bacteria and their metabolites accelerate telomere shortening through oxidative stress pathways, while shortened telomeres compromise gut…
The pursuit of longevity through dietary intervention may have found a previously overlooked molecular pathway that operates independently of the well-studied…
The world's most vulnerable populations remain trapped in cycles of malnutrition despite nearly a decade of coordinated global health initiatives. This…
Just 14 days of head-down tilt bedrest in adults aged 55-65 significantly decreased beneficial gut bacteria including Akkermansia and Lactobacillus while…
Researchers identified MPOL_B_1, a novel geroprotector compound that extends C. elegans lifespan by up to 30% through virtual screening targeting the…
Scientists identified ribonuclease κ (RNASEK) as a critical enzyme that degrades circular RNAs (circRNAs), which accumulate toxically in aging cells. RNASEK…
Advanced mapping techniques reveal that sympathetic nerve density increases in aging ovaries across both human and mouse models, with nerve ablation…
Bioengineers have created artificial liver environments using decellularized extracellular matrix scaffolds that successfully induce dormancy in colorectal…
Clinical evidence reveals semaglutide's therapeutic effects extend far beyond its original diabetes indication, with documented benefits across cardiovascular…
CRISPR-edited human cord blood stem cells carrying the GATA2-R398W mutation display severe mitotic dysfunction and accelerated aging signatures that…
The nonoxidative pentose phosphate pathway, orchestrated by enzymes transketolase and transaldolase, emerges as a critical regulator of CD8+ T cell function…
Adult vaccination appears to fundamentally rewire aging immune systems beyond simple pathogen protection, triggering "trained immunity" that reprograms innate…
Analysis of social network data reveals that problematic individuals within close personal circles—termed 'hasslers'—trigger measurable acceleration in…
Chronic kidney disease represents a significant and underrecognized consequence of SARS-CoV-2 infection, with multiple studies demonstrating elevated CKD risk…
Biogerontology researchers argue that extending human healthspan represents a fundamental ethical obligation rather than merely a beneficial outcome. Their…
The LRRC26 auxiliary subunit fundamentally alters how BK potassium channels respond to voltage changes, enabling activation at resting membrane potentials…
Bioengineers developed implantable pressure sensors using liquid metal that wirelessly transmit cardiovascular data without rigid components or external…
Cognitive resilience, autonomic regulation, sleep architecture, and behavioral capacity emerge as the primary determinants of functional longevity, with…
Researchers propose brainspan as a novel metric measuring the duration of life with sufficient neural network efficiency to maintain autonomy, adaptive…
Two years of caloric restriction in healthy adults produced distinct metabolic signatures across 864 circulating compounds, with three major pathway changes…