APOE2 Allele Shields Neurons from DNA Damage and Senescence via Repair Pathways
For decades, the APOE gene has been studied almost exclusively through the lens of cholesterol transport and Alzheimer's risk — but a growing body of evidence…
Found 1102 results for "longevity"
For decades, the APOE gene has been studied almost exclusively through the lens of cholesterol transport and Alzheimer's risk — but a growing body of evidence…
Why some people reach extreme old age with their cognition largely intact is one of longevity science's most urgent questions. New mechanistic evidence from…
Understanding why the aging brain becomes increasingly vulnerable to neurodegenerative disease is one of the central puzzles in longevity science. A…
The branched-chain amino acid valine has quietly occupied a peripheral role in longevity research compared to its more studied relatives leucine and…
The speed at which a person biologically ages may be partially written in the bacteria living in their gut — a connection with real implications for how…
Selectively eliminating senescent cells — the so-called "zombie cells" that accumulate with age and drive chronic inflammation — remains one of the most…
For clinicians and researchers betting on blood-based RNA signatures to diagnose or monitor disease, a fundamental question has gone underexplored: how much…
The intersection of resource extraction, ecosystem disruption, and infectious disease emergence is rarely captured in a single geographic lens — but the Congo…
Isorhamnetin-3-O-glucoside-7-O-rhamnoside (IGRh), a characteristic sea buckthorn leaf flavonoid, extended lifespan and improved healthspan markers in C…
Mitochondrial health sits at the crossroads of aging and neurodegeneration, yet understanding precisely which neurons are most vulnerable — and why — has…
One of biology's foundational assumptions — that functional traits pass between generations exclusively through genetic material — may need revision. A…
Understanding why the brain deteriorates differently across neurological conditions—Alzheimer's, traumatic brain injury, long COVID—may hinge on a single…
Understanding how the brain encodes behavioral transitions across a lifespan is one of neuroscience's most consequential open questions — not just for…
The assumption that urinary tract infections stay contained rarely survives a case like this. When a common hospital-acquired bacterium acquires the genetic…
For the millions of adults living with HIV who depend on daily medication to maintain viral suppression and near-normal life expectancy, a comprehensive…
Understanding why neuroinflammation persists long after its initial trigger — and why it selectively devastates aging brains — may hinge on mechanisms…
Road injuries remain one of the most preventable sources of premature death and disability on the planet, yet progress toward international safety targets has…
Hypertrophic cardiomyopathy has long been studied as a condition affecting both sexes equally at the genetic level — yet the clinical reality for women is…
More than a million people still die each year from infections most adults in wealthy nations rarely think about — yet the pace of progress against these…
The health of blood vessels may be the single most consequential biological variable governing how well—and how long—people age. A comprehensive review in…